In February of 2012, it was announced that ABC had ordered a pilot for a new drama series The Smart One, one of whose executive producers was listed as Ellen De Generes, and which featured de Rossi in a leading role.
The actress was to star as a "brilliant and successful woman who begrudgingly goes to work for her less-brainy but more popular sister – a former beauty queen, weather girl and now big-city Mayor." Six years after the series was canceled by Fox, filming for a revived fourth season of Arrested Development began on 7 August 2012, and de Rossi reprised her role as Lindsay Bluth Fünke.
In May of 2007, she was featured as one of 100 Most Beautiful in a People special edition.
I will miss playing Elizabeth North but I've made the decision to focus on a business opportunity. " Creator Shonda Rhimes added, "I have been a fan of Portia's for years and it was an honor to have her join our Scandal family." De Rossi was married to documentary film-maker Mel Metcalfe, from 1996 to 1999, initially part of a plan to get a green card, though she did not go through with the plan.In 2011, she appeared in Better Off Ted cast member Malcolm Barrett's music video for "Revenge of the Nerds," spoofing her character of Veronica in a cameo alongside other cast members of the cancelled series.