She is simply magnificent." for Outstanding Actress In a Play for her performance in Desire Under the Elms.
Later in November of that year, she appeared as a pornographic actress in the comedy film Women in Trouble, which spawned a sequel in 2010, Elektra Luxx, titled after her character.
In 2011, Gugino appeared as Madame Vera Gorsky in Zack Snyder's action-fantasy film Sucker Punch alongside Abbie Cornish and Emily Browning.
Gugino sang a duet with co-star Oscar Isaac, which appeared in the end credits and in the film's soundtrack.
She starred in two short-lived TV series: ABC's Elmore Leonard crime drama Karen Sisco in 2003, and CBS's science fiction series Threshold in 2005.
after which she traveled between her father and half-brother Carl Jr.'s home in Sarasota, and her Paradise, California home, to which her mother moved her when she was four.
During the Foundation's 34th Anniversary Gala in Washington, D.
C., she received NIAF's Special Achievement Award for Entertainment, presented by her close friend, actress Connie Britton.
She also guest starred on the fourth season of Californication as Abby Rhodes, Hank Moody's attorney and love interest.
In the mid-2012, Gugino had a lead role as Susan Berg, a Washington D. investigative reporter, on the USA Network's miniseries Political Animals.Charles Isherwood of The New York Times praised Gugino's performance, saying, "Ms.